The Bioanalytical Laboratory offers analytical services in support of compound development for clinical research.  The laboratory is experienced in the areas of analytical method development, transfer, and validation for a variety of small molecule oncology agents. The major services and resources of the Bioanalytical Laboratory include:

1. Multiple HLPC-UV and HPLC-FL instruments
2. LC-MS/MS capabilities
3. Analytical method transfer and validation in accordance with federal regulatory guidelines
4. Bioavailability, drug-drug interaction, and pharmacokinetic studies in collaboration with the Phase I Physician Group
5. Bioavailability, biodistribution, tumor uptake, drug-drug interaction, and pharmacokinetic studies in collaboration with START Laboratory’s Preclinical Research group.
6. Analysis of samples from a variety of biological matrices (plasma, serum, urine, etc.)
7. Quantitative metabolite concentration vs. time profiling
8. Non-compartmental and compartmental pharmacokinetic modeling using WinNonlin and other modeling software